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Association Between Uric Acid and Bone Mineral Density in Postmenopausal Women With Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study

Xin Zhao 1Xiaofeng Yu 1Xiaomei Zhang 1

J Diabetes Res doi: 10.1155/2020/3982831. eCollection 2020.

Abstract

Objective: To analyze the association between uric acid levels and bone mineral density in postmenopausal women with type 2 diabetes mellitus.

Methods: We retrospectively analyzed 262 postmenopausal women with type 2 diabetes mellitus, to assess uric acid levels and bone mineral density using the T score of dual-energy X-ray absorptiometry.

Results: (1) Women in the osteoporosis group demonstrated higher uric acid levels and lower estimated glomerular filtration rate (p < 0.05, respectively). (2) Uric acid levels were positively correlated with the hip and lumbar spine bone mineral density and T score (r = 0.17, p < 0.05; r = 0.25, p < 0.05; r = 0.17, p < 0.05; and r = 0.28, p < 0.05, respectively). Meanwhile, there was a positive relation between estimated glomerular filtration rate and hip bone mineral density (r = 0.22, p < 0.05). (3) Logistic regression analysis showed that age, body mass index, and diabetic duration are independent risk factors for osteoporosis in postmenopausal women with type 2 diabetes mellitus. The level of estimated glomerular filtration rate and uric acid levels were not independent effect factors for osteoporosis in menopausal women.