Turk J Med Sci. 2019 Oct 27. doi: 10.3906/sag-1904-49. [Epub ahead of print]
BACKGROUND AND AIM:
This study aimed to investigate the change in bone mineral density (BMD) before and 1 year after parathyroidectomy in patients with primary hyperparathyroidism (PHPT).
MATERIALS AND METHODS:
The clinical and biochemical parameters and DEXA screening of patients with symptomatic PHPT (n=28) and asymptomatic PHPT (n=63) were investigated before and 1 year after parathyroidectomy.
Patients with symptomatic PHPT had a higher prevalence of nephrolithiasis (18.2 vs. 4.6%, p=0.032) when compared to prevalence in patients with asymptomatic PHPT. The prevalence of osteoporosis in the lumbar spine (63.0 vs. 37.5%, p=0.026) and femoral neck (40.7 vs. 20.6%, p=0.048) was higher in symptomatic PHPT when compared to prevalence in asymptomatic PHPT. After parathyroidectomy, decrease in the prevalence of osteoporosis in lumbar spine (25.8 vs. 9.4%, p=0.014) and femoral neck (22.1 vs. 8.2%, p=0.009) and total hip (22.4 vs. 5.3%, p=0.007) were higher in symptomatic PHPT compared to asymptomatic PHPT group. A higher BMD gain (g/cm2) was seen in lumbar spine (10.83 vs. 4.65%, p=0.016) and femoral neck (12.61 vs. 4.37%, p=0.005) in symptomatic PHPT compared to asymptomatic PHPT group.
Parathyroidectomy provided more BMD gain in the lumbar spine and femoral neck in patients with symptomatic PHPT when compared to patients with asymptomatic PHPT 1-year after parathyroidectomy.