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Transient Familial Factor V Leiden-Linked Hip Osteoporosis

[Article in English, Spanish]

Serrano-Toledano D1Del Río-Arteaga M2Ribera-Zabalbeascoa J3.

Rev Esp Cir Ortop Traumatol. 2020 Mar 27. pii: S1888-4415(20)30003-5. doi: 10.1016/j.recot.2019.12.005. [Epub ahead of print]




Transient osteoporosis of the hip (THO) is a rare disease of unknown pathogenesis that has traditionally been considered an early and reversible stage of avascular necrosis (AN). Thrombophilia or familial hypofibrinolysis is considered a risk factor for the development of AN and THO. Factor V Leiden is one of the most common hereditary hypercoagulability disorders.


Case series study. The development and course of 3THO cases in 3siblings (two males and one female) aged between 40 and 43 years are described consecutively. Clinical and nuclear magnetic resonance imaging (MRI) studies confirmed the diagnosis of THO and ruled out the presence of AN. The G1691A mutation of factor v Leiden was positive in all cases. The clinical and radiological outcome was favourable, with healing without sequelae and disappearance of bone oedema on control MRI at 6 months in all cases.


The results of this study support the ischaemic aetiology and establish HTO as an early and reversable stage of hip AN. Factor V Leiden causes a state of hypercoagulability and hypofibrinolysis that encourages the development of THO due to ischaemic causes.


This study outlines the first familiar description of factor v Leiden-linked THO.