USPSTF weighs in on low-dose vitamin D, calcium for fracture prevention

Draft Recommendation Statement: Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Adults: Preventive Medication. U.S. Preventive Services Task Force. 2017 September.


There is currently no strong evidence that daily supplementation with low-dose vitamin D and calcium prevents fractures in post-menopausal women.

Why this matters

Current practice often recommends patients, especially postmenopausal women, be prescribed daily supplementation of vitamin D and calcium .However, potential harms may occur from this supplementation, and alternatives may help prevent falls that can cause fractures.


Key points

There is insufficient evidence to recommend for or against the use of vitamin D supplementation, alone or in combination with calcium, for the prevention of fractures in men and postmenopausal women

Evidence is insufficient to make recommendations for greater than 400 IU of vitamin D and greater than 1000 mg of calcium in postmenopausal women.

Recommendation against daily use of ≤400 IU vitamin D and ≤1,000 mg calcium for the primary prevention of fractures in postmenopausal women.Potential harms of vitamin D and calcium supplementation include kidney stones in postmenopausal women.


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