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Vertebral fracture during one repetition maximum testing in a breast cancer survivor: A case report

Friederike Rosenberger 1 2Justine Schneider 1 3Kathrin Schlueter 1 3Jean-Luc Paratte 1Joachim Wiskemann 1

Medicine (Baltimore) doi: 10.1097/MD.0000000000025705.

Abstract

Rationale: One repetition maximum (1-RM) testing is a standard strength assessment procedure in clinical exercise intervention trials. Because no adverse events (AEs) are published, expert panels usually consider it safe for patient populations. However, we here report a vertebral fracture during 1-RM testing.

Patient concerns: A 69-year-old breast cancer survivor (body-mass-index 31.6 kg/m2), 3 months after primary therapy, underwent 1-RM testing within an exercise intervention trial. At the leg press, she experienced pain accompanied by a soft crackling.

Diagnosis: Imaging revealed a partially unstable cover plate compression fracture of the fourth lumbar vertebra (L4) with a vertical fracture line to the base plate, an extended bone marrow edema and a relative stenosis of the spinal canal.

Interventions: It was treated with an orthosis and vitamin D supplementation. Another imaging to exclude bone metastases revealed previously unknown osteoporosis.

Outcomes: The patient was symptom-free 6.5 weeks after the event but did not return to exercise.

Conclusion: This case challenges safety of 1-RM testing in elderly clinical populations.

Lessons: Pre-exercise osteoporosis risk assessment might help reducing fracture risk. However, changing the standard procedure from 1-RM to multiple repetition maximum (x-RM) testing in studies with elderly or clinical populations would be the safest solution.