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A systematic review and meta-analysis of vitamin D and calcium in preventing osteoporotic fractures

Eleni A1, Panagiotis P2.

Clin Rheumatol. 2020 May 24. doi: 10.1007/s10067-020-05122-3. [Epub ahead of print]

To assess and update the effect of the combination of vitamin D and calcium in the reduction of osteoporotic fractures, a systematic review across Cochrane Database, NIHR HTA database, PubMed and Google Scholar was performed using mesh terms : Cohort studies OR Prospective Studies OR Longitudinal Studies OR Follow-Up Studies OR Incidence OR Risk OR Rate and Osteoporotic Fractures OR Fractures, Bone OR Fractures, Spontaneous OR Spinal Fractures OR Humeral Fractures OR Hip Fractures OR Femoral Neck Fractures AND Vitamin D AND Calcium and key words: vitamin D, fractures, osteoporosis, calcium, dietary supplements. Statistical analysis was performed with Review Manager (RevMan 5.3) using relative risk and confidence interval 95%. The combination reduced total fractures and hip fractures while no effect was observed in wrist fractures. The combination was also well tolerated. Only minor side effects were reported. This systematic review suggests that the combination of vitamin D and calcium can exert a beneficial effect towards osteoporotic fracture reduction.

Conclusion Fractures beget more factures and in the context of an ageing population, fractures can escalate to a serious public health burden . Therefore, the elucidation and proper utilisation of available treatment modalities can bring about positive impact to patients and society as well. The combination of vitamin D and calcium can yield a beneficial effect on total number of osteoporotic fractures, including hip fractures. Their safety profile and their low cost further support our proposition.