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Bone marrow edema syndrome/transient osteoporosis of the hip joint and management with the utilization of hyperbaric oxygen therapy

Ververidis AN1Paraskevopoulos K2Keskinis A2Ververidis NA3Molla Moustafa R1Tilkeridis K1.

J Orthop. 2020 Mar 31;22:29-32. doi: 10.1016/j.jor.2020.03.062. eCollection 2020 Nov-Dec.



Transient osteoporosis of hip (TOH) is a self-limited condition that affects young and middle aged women or men. The clinical manifestation is characterized by sudden or gradual onset of pain that is exacerbated on weight-bearing and at night. The treatment of TOH is either conservative or surgical. Conservative regimens include restriction of weight-bearing, pharmacological agents such as prostacyclin analogues (iloprost), non-steroid anti-inflammatory drugs (NSAIDs), extracorporeal shock wave and hyperbaric oxygen therapy (HBOT). Surgical intervention includes drilling or core decompression. The aim of this article is to review the clinical entity of TOH (clinical presentation, pathophysiology, diagnosis) and to further discuss the off-label utilization of HBOT as an alternative treatment regimen in patients suffering from TOH that fail to respond to other conservative methods.