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Medical students’ knowledge of Medication Related Osteonecrosis of the Jaw

Franchi S1Brucoli M1Boffano P2Dosio C1Benech A1.

J Stomatol Oral Maxillofac Surg. 2019 Oct 28. pii: S2468-7855(19)30250-2. doi: 10.1016/j.jormas.2019.10.005. [Epub ahead of print]





The objective of this study was to assess medical students’ knowledge of Medication Related Osteonecrosis of the Jaws (MRONJ).


A questionnaire survey was administered to all the medical students in the last two years of school of medicine at the University of Eastern Piedmont between January 2019 and March 2019. The questionnaire contained a first section regarding demographic and personal data of the student and a second section regarding the knowledge on MRONJ.


On the whole, 72 medical students agreed to participate to this study and filled in the questionnaire. As for indications for the use of bisphosphonates 45 students correctly answered «osteoporosis, osteogenesis imperfecta, multiple myeloma, or metastasis of some malignant tumors». Almost all students (71 out of 72) answered that a thorough examination of oral cavity and a dentist screening is needed and fundamental before starting bisphosphonate assumption. As for drugs responsible for MRONJ, only 12 students out of 72 correctly answered «bisphosphonates, denosumab, and antiangiogenic drugs».


A better level of knowledge and awareness by medical doctors and young physicians may lead, in future, to minimize incidence of MRONJ as well as to a better resolution of ONJ cases. Theoretical and practical initiatives could be promoted to improve and consolidate the knowledge of future physicians about this important issue.