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Novel combinatorial transdermal drug delivery of alendronate with risedronate for the treatment of osteoporosis

Kong F1Jia B2Cui P3Wang D4.

Acta Biochim Pol. 2019 Dec 17;66(4):463-467. doi: 10.18388/abp.2019_2863.




The presented investigation explores the efficiency of novel transdermal drug delivery system of combination of two drugs i.e risedronate and alendronate in the treatment of osteoporosis. The nanoparticulate transdermal patch was prepared using PLGA as principle polymer which has been found to be suitable for drug delivery. The novel formulation system was found to be more efficient in lowering and maintaining the plasma calcium at a normal level when compared to a pure drug in a study carried out on an excised rat skin.


The  transdermal  patches  of  ALN-RSD–NP  were  for mulated  successfully  for  anti-osteoporetic  treatment.  The   proposed   formulation   showed   reliable   bioavailability    which  was  six  to  seven  times  higher  than  that  of  pure 

drugs.  The  plasma  calcium  level  was  maintained  by  for mulations  containing  ALN-RSD-NP  which  found  to  be   useful  in  controlling  the  osteoporosis.  These  findings  such  as  enhanced  skin  permeation,  bioavailability  and   the  lower  plasma  calcium  level  after  transdermal  delivery   suggest  that  this  is  a  promising  approach  for  the  treatment  of  osteoporosis