Acta Biochim Pol. 2019 Dec 17;66(4):463-467. doi: 10.18388/abp.2019_2863.
The presented investigation explores the efficiency of novel transdermal drug delivery system of combination of two drugs i.e risedronate and alendronate in the treatment of osteoporosis. The nanoparticulate transdermal patch was prepared using PLGA as principle polymer which has been found to be suitable for drug delivery. The novel formulation system was found to be more efficient in lowering and maintaining the plasma calcium at a normal level when compared to a pure drug in a study carried out on an excised rat skin.
The transdermal patches of ALN-RSD–NP were for mulated successfully for anti-osteoporetic treatment. The proposed formulation showed reliable bioavailability which was six to seven times higher than that of pure
drugs. The plasma calcium level was maintained by for mulations containing ALN-RSD-NP which found to be useful in controlling the osteoporosis. These findings such as enhanced skin permeation, bioavailability and the lower plasma calcium level after transdermal delivery suggest that this is a promising approach for the treatment of osteoporosis