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Purified and Specific Cytoplasmic Pollen Extract: A Non-Hormonal Alternative for the Treatment of Menopausal Symptoms

Andrea Genazzani 1, Nick Panay 2, Tommaso Simoncini 3, Herman Depypere 4, Alfred Mueck 5 6, Christian Egarter 7, Nicoletta Biglia 8, Tomas Fait 9, Martin Birkhaeuser 10, Sven O Skouby 11, Mark Brincat 12, Steven Goldstein 13, Xiangyan Ruan 5 6, Cuauhtémoc Celis-Gonzales 14, Santiago Palacios 15

DOI: 10.1080/09513590.2020.1722994

Abstract
Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin®. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin® in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin®, an SSRI-‘like’ therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin® may also be a suitable option for the management of menopausal symptoms in women with breast cancer.