Souftas V1, Deuteraiou D2, Anthoulaki X2, Chalkidou A2, Bothou A3, Gaidatzi F2, Tsypsianis G4, Iatrakis G5, Zervoudis S4, Souftas D6, Michalopoulos S2, Vogiatzaki T7, Galazios G2, Nikolettos N2, Tsikouras P2.
Exp Ther Med. 2020 Jun;19(6):3684-3690. doi: 10.3892/etm.2020.8652. Epub 2020 Apr 9.
The purpose of the present study was to describe the course of changes in laboratory inflammatory markers following bilateral uterine artery embolization (UAE) as a treatment for leiomyomas and adenomyosis. The body temperature was measured and blood samples were collected to determine white blood cell (WBC) count and C-reactive protein (CRP) levels in 270 patients on the day prior to UAE and for up to 4 days post-embolization. Aside from a single case with a non-inflammatory complication, none of the other cases had any complications. Post-UAE leukocytosis with a mean maximum value of 10.8±3.5×109/l (range, 5.9-18.6×109/l) was observed one-year post-intervention. The mean leukocyte numbers were indicated to be higher on day 3 post-UAE. The CRP level was also increased post-UAE, with a mean maximum value of 7.75±3.5 mg/dl. Maximum levels were reached in 8 patients on the 2nd and in 11 patients on the 3rd post-operative day. The maximum pain score was ~5.5 and reached its lowest level at the end of the 12th week post-intervention. The present study did not consider an association between the embolic material used or uterus size with the level of treatment success. No complications were observed post-UAE; however, a significant increase in the WBC count was observed within the first 3 days, indicating mild leukocytosis.